SS-31 10 mg

Overview

SS-31 (Elamipretide / MTP-131) is a research-grade synthetic tetrapeptide studied extensively in laboratory research involving mitochondrial biology, cardiolipin interactions, mitochondrial membrane organization, cellular bioenergetics, and oxidative stress pathways.

NextCell Peptides supplies SS-31 10 mg as a professionally labeled, lyophilized research peptide intended exclusively for laboratory and analytical research. Each product is clearly identified and supplied with batch traceability to support consistent research workflows.

SS-31 belongs to the Szeto-Schiller peptide family and has been investigated for its ability to interact selectively with cardiolipin, a phospholipid concentrated within the inner mitochondrial membrane. This makes SS-31 an important research compound for investigating mitochondrial membrane structure and cellular energy-related processes.

Product Specifications

Product
SS-31 (Elamipretide / MTP-131)

Quantity
10 mg

Appearance
White to off-white lyophilized powder

Sequence
D-Arg-Dmt-Lys-Phe-NH₂

Molecular Weight
639.8 g/mol

Molecular Formula
C₃₂H₄₉N₉O₅

CAS Number
736992-21-5

Peptide Type
Synthetic tetrapeptide

Purity
≥99% (HPLC)

Grade
Research Grade

What Is SS-31?

SS-31 is a synthetic tetrapeptide also known as Elamipretide, MTP-131, Bendavia, and Szeto-Schiller peptide 31.

The peptide consists of four amino-acid residues and contains 2,6-dimethyltyrosine (Dmt) as part of its structure. Its sequence is:

D-Arg-Dmt-Lys-Phe-NH₂

SS-31 has attracted significant research interest because of its interaction with cardiolipin, a distinctive phospholipid located within the inner mitochondrial membrane.

Unlike many conventional peptides investigated in biological systems, SS-31 has specifically been studied for its mitochondrial membrane-associated properties and its relationship with cardiolipin-rich membrane environments.

Common Laboratory Applications

SS-31 is investigated in laboratory research involving:

Mitochondrial biology
Cardiolipin research
Inner mitochondrial membrane studies
Mitochondrial membrane organization
Cellular bioenergetics
Oxidative stress research
Mitochondrial signaling
Membrane protein research
Cellular metabolism
Mitochondrial morphology
Peptide pharmacology
Molecular and cellular biology

The specific application depends on the experimental model, analytical method, and research objectives.

Why Is SS-31 Studied?

Mitochondria contain a specialized inner membrane that is highly enriched in cardiolipin, a phospholipid involved in maintaining membrane architecture and supporting the organization of mitochondrial respiratory machinery.

SS-31 has been studied because of its ability to interact with cardiolipin and associate with the inner mitochondrial membrane. Research into this interaction has focused on membrane structure, mitochondrial organization, respiratory-chain function, and cellular bioenergetics.

This makes SS-31 particularly relevant to experimental studies investigating the relationship between mitochondrial membranes, cardiolipin, cellular energy metabolism, and mitochondrial function.

SS-31 and Cardiolipin Research

One of the defining characteristics of SS-31 research is its relationship with cardiolipin.

Cardiolipin is a unique phospholipid predominantly associated with the inner mitochondrial membrane. It contributes to mitochondrial membrane architecture and the organization of respiratory-chain components.

Research involving elamipretide has investigated how interaction with cardiolipin may influence mitochondrial membrane structure, cristae organization, and mitochondrial bioenergetic processes.

Because of this specific membrane interaction, SS-31 is frequently used as a research tool in experimental models examining cardiolipin biology, mitochondrial membranes, membrane-associated signaling, and cellular bioenergetics.

Research-Grade SS-31 Quality Considerations

When evaluating research-grade SS-31, researchers should consider more than the stated purity alone.

Important quality and documentation factors include:

HPLC purity analysis
Peptide identity confirmation
Molecular weight verification
Sequence confirmation
Batch-specific Certificate of Analysis (COA)
Lot and batch traceability
Manufacturing consistency
Packaging integrity
Storage recommendations

NextCell Peptides provides clear product identification and batch documentation to support laboratory traceability and informed research workflows.

Storage & Handling

Store the lyophilized peptide according to the storage conditions specified in the applicable product and batch documentation.

Protect the material from excessive heat, moisture, and direct light. Appropriate laboratory handling procedures should be followed when working with research peptides, including minimizing unnecessary exposure to environmental conditions that could compromise sample integrity.

For specific storage requirements, researchers should always refer to the applicable Certificate of Analysis and batch documentation supplied with the product.

Frequently Asked Questions

What is SS-31?

SS-31 is a synthetic tetrapeptide also known as Elamipretide, MTP-131, Bendavia, and Szeto-Schiller peptide 31. It is studied primarily in laboratory research involving mitochondrial biology and cardiolipin interactions.

What is the sequence of SS-31?

The SS-31 sequence is:

D-Arg-Dmt-Lys-Phe-NH₂

where Dmt refers to 2,6-dimethyltyrosine.

What is the molecular weight of SS-31?

SS-31 has a reported molecular weight of approximately 639.8 g/mol for the free compound.

What is Elamipretide?

Elamipretide is another name for SS-31, also known as MTP-131. The compound has been extensively investigated in mitochondrial and cardiolipin research.

What is cardiolipin?

Cardiolipin is a distinctive phospholipid concentrated in the inner mitochondrial membrane. It plays an important structural role in mitochondrial membrane organization and the organization of respiratory-chain components.

What is SS-31 studied for?

SS-31 is studied in areas including mitochondrial biology, cardiolipin research, mitochondrial membrane organization, cellular bioenergetics, oxidative stress research, and molecular biology.

Is SS-31 the same as MTP-131?

Yes. SS-31, Elamipretide, and MTP-131 are names associated with the same peptide compound.

Is a Certificate of Analysis available?

Batch-specific product documentation, including a Certificate of Analysis (COA) where applicable, can be used to support product identity, purity assessment, and batch traceability.

Research Use Only

SS-31 10 mg is supplied exclusively for laboratory research and analytical purposes.

This product is not intended for human consumption, self-administration, veterinary use, therapeutic use, diagnosis, treatment, or prevention of disease. It is not supplied as a pharmaceutical product or medicine.

Researchers are responsible for ensuring that their use, handling, storage, and disposal of research materials comply with all applicable institutional and local requirements.

Obs: Om din leverantörs COA anger att just din SS-31 är en TFA- eller HCl-saltform, bör molecular weight och chemical form i produktinformationen matcha COA:n i stället för free-base-värdet 639.8 g/mol.